A Randomized, Controlled Trial of Vitamin D Supplementation upon Musculoskeletal Health in Postmenarchal Females.
J Clin Endocrinol Metab. 2010 Jul 14. Epub ahead of print
Ward KA, Das G, Roberts SA, Berry JL, Adams JE, Rawer R, Mughal MZ.
Medical Research Council Human Nutrition Research (K.A.W.), Cambridge CB1 9NL, United Kingdom; Imaging Science Research Group (K.A.W., J.E.A.), University of Manchester, Manchester M13 9PL, United Kingdom; Central Manchester Primary Care National Health Service (NHS) Trust (G.D.), Manchester M21 7RL, United Kingdom; Health Methodology Research Group (S.A.R.), University of Manchester, Manchester Academic Health Science Centre Manchester M13 9PL, United Kingdom; Vitamin D Research Group (J.L.B.), Endocrine Sciences, University of Manchester, Manchester M13 9PL, United Kingdom; Novotec Medical GmBH (R.R.), 75172 Pforzheim, Germany; and Manchester Royal Infirmary (J.E.A.), Royal Manchester Children's Hospital (M.Z.M.), Central Manchester University Hospitals Foundation NHS Trust, Manchester M13 9WL, United Kingdom.
Context:There has been a resurgence of vitamin D deficiency rickets throughout the developed world, with infants and adolescents being primarily affected. Adolescence is a crucial period for muscle and bone mineral accumulation.
Objective: The aim was to determine the effect of vitamin D supplementation on the adolescent musculoskeletal system. Design and Setting: We conducted a community-based, double-blind, randomized controlled trial in a secondary school. Participants: Postmenarchal 12- to 14-yr-old females participated in the trial. Ninety-nine were screened, 73 were included in randomized controlled trial, and 69 completed the trial. There were no adverse events. Intervention:
Four doses of 150,000 IU vitamin D2 (ergocalciferol) were given over 1 yr. Main Outcome Measures: Dual-energy x-ray absorptiometry, peripheral quantitative computed tomography, and jumping mechanography were used.
Results: At follow-up, 25-hydroxyvitamin D 25(OH)D status was 56.0 +/- 8.9 nmol/liter in the intervention group (approx 22 ng/ml) and 15.8 +/- 6.6 nmol/liter in controls. There were no effects of supplementation on bone; however, for muscle function, efficiency of movement improved in the vitamin D-treated group. There was an interaction between baseline 25(OH)D concentration and response to vitamin D supplementation for muscle jump velocity.
Conclusions: Despite improvements in 25(OH)D status, treatment with vitamin D2 was not shown to increase mineral accretion, bone geometry or strength, muscle force, or power. There were greater increases in jump velocity in girls with the lowest baseline 25(OH)D concentrations. Lack of effect of intervention after the period of peak mineral and muscle mass accretion suggests that earlier action is required. PMID: 20631020
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Suspect than 3000 IU of vitamin D3 on a monthly or more frequent basis would have been affective